5L2W

The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.

Summary for 5L2W

Entry DOI	10.2210/pdb5l2w/pdb
Related	5L2I 5L2S 5L2T
Descriptor	Cyclin-dependent kinase 2, G1/S-specific cyclin-E1, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, ... (5 entities in total)
Functional Keywords	cyclin-dependent kinase, kinase inhibitor, kinase selectivity, transferase-cell cycle-inhibitor complex, transferase/cell cycle/inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941 Nucleus : P24864
Total number of polymer chains	2
Total formula weight	70323.40
Authors	Chen, P.,Ferre, R.A.,Deihl, W.,Yu, X.,He, Y.-A. (deposition date: 2016-08-02, release date: 2016-08-24, Last modification date: 2023-10-04)
Primary citation	Chen, P.,Lee, N.V.,Hu, W.,Xu, M.,Ferre, R.A.,Lam, H.,Bergqvist, S.,Solowiej, J.,Diehl, W.,He, Y.A.,Yu, X.,Nagata, A.,VanArsdale, T.,Murray, B.W. Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol.Cancer Ther., 15:2273-2281, 2016 Cited by PubMed: 27496135 DOI: 10.1158/1535-7163.MCT-16-0300 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation