5L2I
The X-ray co-crystal structure of human CDK6 and Palbociclib.
Summary for 5L2I
| Entry DOI | 10.2210/pdb5l2i/pdb |
| Related | 5L2S 5L2T 5L2W |
| Descriptor | Cyclin-dependent kinase 6, 6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE (2 entities in total) |
| Functional Keywords | cyclin-dependent kinase, kinase inhibitor, kinase selectivity, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm: Q00534 |
| Total number of polymer chains | 1 |
| Total formula weight | 35466.75 |
| Authors | Chen, P.,Ferre, R.A.,Deihl, W.,Yu, X.,He, Y.-A. (deposition date: 2016-08-01, release date: 2016-08-24, Last modification date: 2023-10-04) |
| Primary citation | Chen, P.,Lee, N.V.,Hu, W.,Xu, M.,Ferre, R.A.,Lam, H.,Bergqvist, S.,Solowiej, J.,Diehl, W.,He, Y.A.,Yu, X.,Nagata, A.,VanArsdale, T.,Murray, B.W. Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol.Cancer Ther., 15:2273-2281, 2016 Cited by PubMed: 27496135DOI: 10.1158/1535-7163.MCT-16-0300 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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