5L2F

High Resolution Structure of Acinetobacter baumannii beta-lactamase OXA-51 I129L/K83D bound to doripenem

Summary for 5L2F

• Entry DOI: 10.2210/pdb5l2f/pdb
• Related: 5KZH
• Descriptor: Beta-lactamase, (4R,5S)-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-3-({(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid, ACETATE ION, ... (5 entities in total)
• Functional Keywords: hydrolase, antibiotic, beta-lactamase, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 4
• Total formula weight: 114855.60

Authors

June, C.M.,Powers, R.A.,Leonard, D.A.,Muckenthaler, T. (deposition date: 2016-08-01, release date: 2016-09-28, Last modification date: 2023-10-04)

• Primary citation: June, C.M.,Muckenthaler, T.J.,Schroder, E.C.,Klamer, Z.L.,Wawrzak, Z.,Powers, R.A.,Szarecka, A.,Leonard, D.A.; The structure of a doripenem-bound OXA-51 class D beta-lactamase variant with enhanced carbapenemase activity.; Protein Sci., 25:2152-2163, 2016; PubMed: 27636561; DOI: 10.1002/pro.3040

Experimental method

X-RAY DIFFRACTION (1.77 Å)