5L1G

AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br

Summary for 5L1G

Entry DOI	10.2210/pdb5l1g/pdb
Related	5L1B 5L1E 5L1F 5L1H
Descriptor	Glutamate receptor 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide (3 entities in total)
Functional Keywords	transporter, membrane protein, transport protein, transport protein-inhibitor complex, transport protein/inhibitor
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	362264.18
Authors	Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Sobolevsky, A.I. (deposition date: 2016-07-29, release date: 2016-10-19, Last modification date: 2023-10-04)
Primary citation	Yelshanskaya, M.V.,Singh, A.K.,Sampson, J.M.,Narangoda, C.,Kurnikova, M.,Sobolevsky, A.I. Structural Bases of Noncompetitive Inhibition of AMPA-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs. Neuron, 91:1305-1315, 2016 Cited by PubMed: 27618672 DOI: 10.1016/j.neuron.2016.08.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (4.507 Å)

Structure validation