5L0Q

Crystal structure of the complex between ADAM10 D+C domain and a conformation specific mAb 8C7.

Summary for 5L0Q

• Entry DOI: 10.2210/pdb5l0q/pdb
• Descriptor: Disintegrin and metalloproteinase domain-containing protein 10, mAb 8C7 light chain, mAb 8C7 heavy chain, ... (7 entities in total)
• Functional Keywords: adam protease, mab, 8c7, notch signaling, therapeutic antibody, cancer stem cell, drug resistance, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Bos taurus (Bovine); More
• Total number of polymer chains: 6
• Total formula weight: 141029.31

Authors

Xu, K.,Saha, N.,Nikolov, D.B. (deposition date: 2016-07-28, release date: 2016-11-09, Last modification date: 2023-10-04)

• Primary citation: Atapattu, L.,Saha, N.,Chheang, C.,Eissman, M.F.,Xu, K.,Vail, M.E.,Hii, L.,Llerena, C.,Liu, Z.,Horvay, K.,Abud, H.E.,Kusebauch, U.,Moritz, R.L.,Ding, B.S.,Cao, Z.,Rafii, S.,Ernst, M.,Scott, A.M.,Nikolov, D.B.,Lackmann, M.,Janes, P.W.; An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth.; J.Exp.Med., 213:1741-1757, 2016; PubMed: 27503072; DOI: 10.1084/jem.20151095

Experimental method

X-RAY DIFFRACTION (2.759 Å)