5KSX
Crystal structure of human FPPS in complex with an allosteric inhibitor AM-02-072
Summary for 5KSX
| Entry DOI | 10.2210/pdb5ksx/pdb |
| Descriptor | Farnesyl pyrophosphate synthase, PHOSPHATE ION, [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid, ... (4 entities in total) |
| Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm: P14324 |
| Total number of polymer chains | 1 |
| Total formula weight | 44176.88 |
| Authors | Park, J.,Matralis, A.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2016-07-10, release date: 2017-03-15, Last modification date: 2023-10-04) |
| Primary citation | Park, J.,Leung, C.Y.,Matralis, A.N.,Lacbay, C.M.,Tsakos, M.,Fernandez De Troconiz, G.,Berghuis, A.M.,Tsantrizos, Y.S. Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. J. Med. Chem., 60:2119-2134, 2017 Cited by PubMed: 28208018DOI: 10.1021/acs.jmedchem.6b01888 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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