5KR0

Protease E35D-APV

Summary for 5KR0

• Entry DOI: 10.2210/pdb5kr0/pdb
• Related: 5KQX 5KQY 5KQZ 5KR1 5KR2
• Descriptor: Protease E35D-APV, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, GLYCEROL, ... (4 entities in total)
• Functional Keywords: hiv-1 protease, e35d, salt-bridge interaction, natural polymorphism, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22049.05

Authors

Liu, Z.,Poole, K.M.,Mahon, B.P.,McKenna, R.,Fanucci, G.E. (deposition date: 2016-07-06, release date: 2016-09-21, Last modification date: 2024-03-06)

• Primary citation: Liu, Z.,Huang, X.,Hu, L.,Pham, L.,Poole, K.M.,Tang, Y.,Mahon, B.P.,Tang, W.,Li, K.,Goldfarb, N.E.,Dunn, B.M.,McKenna, R.,Fanucci, G.E.; Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.; J.Biol.Chem., 291:22741-22756, 2016; PubMed: 27576689; DOI: 10.1074/jbc.M116.747568

Experimental method

X-RAY DIFFRACTION (1.8 Å)