5KMN

TrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea

Summary for 5KMN

• Entry DOI: 10.2210/pdb5kmn/pdb
• Related: 5KMI 5KMJ 5KMK 5KML 5KMM 5KMO
• Descriptor: High affinity nerve growth factor receptor, 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea (3 entities in total)
• Functional Keywords: kinase, juxtamembrane, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 37679.16

Authors

Su, H.P. (deposition date: 2016-06-27, release date: 2016-12-28, Last modification date: 2017-02-01)

• Primary citation: Su, H.P.,Rickert, K.,Burlein, C.,Narayan, K.,Bukhtiyarova, M.,Hurzy, D.M.,Stump, C.A.,Zhang, X.,Reid, J.,Krasowska-Zoladek, A.,Tummala, S.,Shipman, J.M.,Kornienko, M.,Lemaire, P.A.,Krosky, D.,Heller, A.,Achab, A.,Chamberlin, C.,Saradjian, P.,Sauvagnat, B.,Yang, X.,Ziebell, M.R.,Nickbarg, E.,Sanders, J.M.,Bilodeau, M.T.,Carroll, S.S.,Lumb, K.J.,Soisson, S.M.,Henze, D.A.,Cooke, A.J.; Structural characterization of nonactive site, TrkA-selective kinase inhibitors.; Proc. Natl. Acad. Sci. U.S.A., 114:E297-E306, 2017; PubMed: 28039433; DOI: 10.1073/pnas.1611577114

Experimental method

X-RAY DIFFRACTION (2.14 Å)