5KMJ

TrkA JM-kinase with {N}-(2-pyridylmethyl)-2-[2-(2-thienyl)indol-1-yl]acetamide

Summary for 5KMJ

• Entry DOI: 10.2210/pdb5kmj/pdb
• Related: 5KMI 5KMK 5KML 5KMM 5KMN 5KMO
• Descriptor: High affinity nerve growth factor receptor, ~{N}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide (3 entities in total)
• Functional Keywords: kinase, juxtamembrane, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P04629
• Total number of polymer chains: 1
• Total formula weight: 37614.18

Authors

Su, H.P. (deposition date: 2016-06-27, release date: 2016-12-28, Last modification date: 2023-09-27)

• Primary citation: Su, H.P.,Rickert, K.,Burlein, C.,Narayan, K.,Bukhtiyarova, M.,Hurzy, D.M.,Stump, C.A.,Zhang, X.,Reid, J.,Krasowska-Zoladek, A.,Tummala, S.,Shipman, J.M.,Kornienko, M.,Lemaire, P.A.,Krosky, D.,Heller, A.,Achab, A.,Chamberlin, C.,Saradjian, P.,Sauvagnat, B.,Yang, X.,Ziebell, M.R.,Nickbarg, E.,Sanders, J.M.,Bilodeau, M.T.,Carroll, S.S.,Lumb, K.J.,Soisson, S.M.,Henze, D.A.,Cooke, A.J.; Structural characterization of nonactive site, TrkA-selective kinase inhibitors.; Proc. Natl. Acad. Sci. U.S.A., 114:E297-E306, 2017; PubMed: 28039433; DOI: 10.1073/pnas.1611577114

Experimental method

X-RAY DIFFRACTION (2.04 Å)