5KM4

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-5-Iodo-UMP complex

Summary for 5KM4

Entry DOI	10.2210/pdb5km4/pdb
Related	3TW2 5IPB 5IPC 5IPD 5IPE 5KLY 5KLZ 5KM0 5KM1 5KM2 5KM3 5KM5 5KM6 5KM7 5KM8 5KM9 5KMA 5KMB 5KMC
Descriptor	Histidine triad nucleotide-binding protein 1, 5-IODOURIDINE-5'-MONOPHOSPHATE (3 entities in total)
Functional Keywords	hint, histidine triad, hit, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P49773
Total number of polymer chains	2
Total formula weight	28642.45
Authors	Maize, K.M.,Finzel, B.C. (deposition date: 2016-06-26, release date: 2017-06-28, Last modification date: 2023-09-27)
Primary citation	Maize, K.M.,Shah, R.,Strom, A.,Kumarapperuma, S.,Zhou, A.,Wagner, C.R.,Finzel, B.C. A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14:3987-3997, 2017 Cited by PubMed: 28968488 DOI: 10.1021/acs.molpharmaceut.7b00664 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation