5KH3

Crystal structure of fragment (3-(5-Chloro-1,3-benzothiazol-2-yl)propanoic acid) bound in the ubiquitin binding pocket of the HDAC6 zinc-finger domain

5KH3 の概要

• エントリーDOI: 10.2210/pdb5kh3/pdb
• 分子名称: Histone deacetylase 6, ZINC ION, UNKNOWN ATOM OR ION, ... (5 entities in total)
• 機能のキーワード: histone deacetylase, hdac, hdac6, fragment screening, structural genomics consortium, sgc, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13220.85

構造登録者

Harding, R.J.,Dong, A.,Ravichandran, M.,Ferreira de Freitas, R.,Schapira, M.,Bountra, C.,Edwards, A.M.,Santhakumar, V.,Arrowsmith, C.M.,Structural Genomics Consortium (SGC) (登録日: 2016-06-14, 公開日: 2016-07-27, 最終更新日: 2023-09-27)

• 主引用文献: Harding, R.J.,Ferreira de Freitas, R.,Collins, P.,Franzoni, I.,Ravichandran, M.,Ouyang, H.,Juarez-Ornelas, K.A.,Lautens, M.,Schapira, M.,von Delft, F.,Santhakumar, V.,Arrowsmith, C.H.; Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin.; J. Med. Chem., 60:9090-9096, 2017; PubMed: 29019676; DOI: 10.1021/acs.jmedchem.7b00933

実験手法

X-RAY DIFFRACTION (1.6 Å)