5KDE

Inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inhibitor 1 and inorganic pyrophosphate

Summary for 5KDE

Entry DOI	10.2210/pdb5kde/pdb
Related	4Z74 5KDF
Descriptor	Inorganic pyrophosphatase, 2,4-bis(aziridin-1-yl)-6-(1-phenylpyrrol-2-yl)-1,3,5-triazine, PYROPHOSPHATE 2-, ... (4 entities in total)
Functional Keywords	hydrolase, pyrophosphatase, drug target, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Cellular location	Cytoplasm : P9WI55
Total number of polymer chains	1
Total formula weight	19935.17
Authors	Pang, A.H.,Garzan, A.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2016-06-08, release date: 2016-09-28, Last modification date: 2023-09-27)
Primary citation	Pang, A.H.,Garzan, A.,Larsen, M.J.,McQuade, T.J.,Garneau-Tsodikova, S.,Tsodikov, O.V. Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem. Biol., 11:3084-3092, 2016 Cited by PubMed: 27622287 DOI: 10.1021/acschembio.6b00510 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation