5KCJ

Structure of the human GluN1/GluN2A LBD in complex with GNE6901

Replaces:  5H8R

Summary for 5KCJ

• Entry DOI: 10.2210/pdb5kcj/pdb
• Related: 5H8F 5H8H 5H8N 5H8Q 5H8S
• Descriptor: Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, ACETATE ION, ... (7 entities in total)
• Functional Keywords: grin1, grin2a, nmda receptor, glycine, glutamate, transport protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: Q12879 Q05586
• Total number of polymer chains: 2
• Total formula weight: 65934.16

Authors

Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-06-06, release date: 2016-07-13)

• Primary citation: Hackos, D.H.,Lupardus, P.J.,Grand, T.,Chen, Y.,Wang, T.M.,Reynen, P.,Gustafson, A.,Wallweber, H.J.,Volgraf, M.,Sellers, B.D.,Schwarz, J.B.,Paoletti, P.,Sheng, M.,Zhou, Q.,Hanson, J.E.; Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.; Neuron, 89:983-999, 2016; PubMed: 26875626; DOI: 10.1016/j.neuron.2016.01.016

Experimental method

X-RAY DIFFRACTION (2.09 Å)