5KBR

Pak1 in complex with 7-azaindole inhibitor

Summary for 5KBR

• Entry DOI: 10.2210/pdb5kbr/pdb
• Descriptor: Serine/threonine-protein kinase PAK 1, (4-chlorophenyl)-[5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]methanone (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase pak1, kinase, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q13153
• Total number of polymer chains: 2
• Total formula weight: 65476.45

Authors

Ferguson, A. (deposition date: 2016-06-03, release date: 2016-09-28, Last modification date: 2023-09-27)

• Primary citation: McCoull, W.,Hennessy, E.J.,Blades, K.,Chuaqui, C.,Dowling, J.E.,Ferguson, A.D.,Goldberg, F.W.,Howe, N.,Jones, C.R.,Kemmitt, P.D.,Lamont, G.,Varnes, J.G.,Ward, R.A.,Yang, B.; Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.; ACS Med Chem Lett, 7:1118-1123, 2016; PubMed: 27994749; DOI: 10.1021/acsmedchemlett.6b00322

Experimental method

X-RAY DIFFRACTION (2.36 Å)