5K6H

Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C variant.

Summary for 5K6H

Entry DOI	10.2210/pdb5k6h/pdb
Related	5K6B 5K6C 5K6F 5K6G 5K6I
Descriptor	Fusion glycoprotein F0 (2 entities in total)
Functional Keywords	respiratory syncytial virus, prefusion, vaccine, stabilized, viral protein
Biological source	Human respiratory syncytial virus A (strain A2)
Cellular location	Virion membrane; Single-pass type I membrane protein: P03420
Total number of polymer chains	1
Total formula weight	49217.16
Authors	Joyce, M.G.,Zhang, B.,Mascola, J.R.,Kwong, P.D. (deposition date: 2016-05-24, release date: 2016-09-21)
Primary citation	Joyce, M.G.,Zhang, B.,Ou, L.,Chen, M.,Chuang, G.Y.,Druz, A.,Kong, W.P.,Lai, Y.T.,Rundlet, E.J.,Tsybovsky, Y.,Yang, Y.,Georgiev, I.S.,Guttman, M.,Lees, C.R.,Pancera, M.,Sastry, M.,Soto, C.,Stewart-Jones, G.B.,Thomas, P.V.,Van Galen, J.G.,Baxa, U.,Lee, K.K.,Mascola, J.R.,Graham, B.S.,Kwong, P.D. Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV. Nat.Struct.Mol.Biol., 23:811-820, 2016 Cited by PubMed: 27478931 DOI: 10.1038/nsmb.3267 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.648 Å)

Structure validation