5K5M

Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27

5K5M の概要

• エントリーDOI: 10.2210/pdb5k5m/pdb
• 分子名称: RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ... (5 entities in total)
• 機能のキーワード: rna dependent rna polymerase, dengue, hydrolase
• 由来する生物種: Dengue virus 2
• 細胞内の位置: Virion membrane ; Multi-pass membrane protein : B5LNH6
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74590.49

構造登録者

Arora, R.,Benson, T.E. (登録日: 2016-05-23, 公開日: 2016-08-24, 最終更新日: 2024-03-06)

• 主引用文献: Lim, S.P.,Noble, C.G.,Seh, C.C.,Soh, T.S.,El Sahili, A.,Chan, G.K.,Lescar, J.,Arora, R.,Benson, T.,Nilar, S.,Manjunatha, U.,Wan, K.F.,Dong, H.,Xie, X.,Shi, P.Y.,Yokokawa, F.; Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.; Plos Pathog., 12:e1005737-e1005737, 2016; PubMed: 27500641; DOI: 10.1371/journal.ppat.1005737

実験手法

X-RAY DIFFRACTION (2.01 Å)