5K5M

Co-Crystal Structure of Dengue Virus Serotype 2 RNA Dependent RNA Polymerase with Compound 27

Summary for 5K5M

Entry DOI	10.2210/pdb5k5m/pdb
Descriptor	RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ... (5 entities in total)
Functional Keywords	rna dependent rna polymerase, dengue, hydrolase
Biological source	Dengue virus 2
Cellular location	Virion membrane ; Multi-pass membrane protein : B5LNH6
Total number of polymer chains	1
Total formula weight	74590.49
Authors	Arora, R.,Benson, T.E. (deposition date: 2016-05-23, release date: 2016-08-24, Last modification date: 2024-03-06)
Primary citation	Lim, S.P.,Noble, C.G.,Seh, C.C.,Soh, T.S.,El Sahili, A.,Chan, G.K.,Lescar, J.,Arora, R.,Benson, T.,Nilar, S.,Manjunatha, U.,Wan, K.F.,Dong, H.,Xie, X.,Shi, P.Y.,Yokokawa, F. Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling. Plos Pathog., 12:e1005737-e1005737, 2016 Cited by PubMed: 27500641 DOI: 10.1371/journal.ppat.1005737 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation