5JXY

Enzyme-substrate complex of TDG catalytic domain bound to a G/U analog

Summary for 5JXY

• Entry DOI: 10.2210/pdb5jxy/pdb
• Related: 3UFJ 5HF7
• Descriptor: G/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), ... (4 entities in total)
• Functional Keywords: protein-dna complex, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q13569
• Total number of polymer chains: 3
• Total formula weight: 40302.73

Authors

Pidugu, L.S.,Pozharski, E.,Malik, S.S.,Drohat, A.C. (deposition date: 2016-05-13, release date: 2016-09-28, Last modification date: 2023-09-27)

• Primary citation: Coey, C.T.,Malik, S.S.,Pidugu, L.S.,Varney, K.M.,Pozharski, E.,Drohat, A.C.; Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues.; Nucleic Acids Res., 44:10248-10258, 2016; PubMed: 27580719; DOI: 10.1093/nar/gkw768

Experimental method

X-RAY DIFFRACTION (1.71 Å)