5JTY

Glutamate- and DCKA-bound GluN1/GluN2A agonist binding domains with MPX-007

Summary for 5JTY

• Entry DOI: 10.2210/pdb5jty/pdb
• Related: 5I57 5I58 5I59
• Descriptor: Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A, 4-hydroxy-5,7-dimethylquinoline-2-carboxylic acid, ... (6 entities in total)
• Functional Keywords: nmda receptor, antagonist, transport protein, receptor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cell membrane ; Multi-pass membrane protein : P35439 Q00959
• Total number of polymer chains: 2
• Total formula weight: 65690.92

Authors

Mou, T.-C.,Sprang, S.R.,Hansen, K.B. (deposition date: 2016-05-10, release date: 2016-09-21, Last modification date: 2023-09-27)

• Primary citation: Yi, F.,Mou, T.C.,Dorsett, K.N.,Volkmann, R.A.,Menniti, F.S.,Sprang, S.R.,Hansen, K.B.; Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.; Neuron, 91:1316-1329, 2016; PubMed: 27618671; DOI: 10.1016/j.neuron.2016.08.014

Experimental method

X-RAY DIFFRACTION (2.72 Å)