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5JQ5

Crystal structure of CDK2 in complex with inhibitor ICEC0942

Summary for 5JQ5
Entry DOI10.2210/pdb5jq5/pdb
DescriptorCyclin-dependent kinase 2, ACETATE ION, (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, ... (4 entities in total)
Functional Keywordscdk2, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Total number of polymer chains1
Total formula weight34430.04
Authors
Hazel, P.,Freemont, P.S. (deposition date: 2016-05-04, release date: 2017-02-08, Last modification date: 2024-01-10)
Primary citationHazel, P.,Kroll, S.H.,Bondke, A.,Barbazanges, M.,Patel, H.,Fuchter, M.J.,Coombes, R.C.,Ali, S.,Barrett, A.G.,Freemont, P.S.
Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.
ChemMedChem, 12:372-380, 2017
Cited by
PubMed: 28125165
DOI: 10.1002/cmdc.201600535
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.94 Å)
Structure validation

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