5JO0

Structure of Plasmodium falciparum DXR in complex with a beta-substituted fosmidomycin analogue, LC56 and manganese

5JO0 の概要

• エントリーDOI: 10.2210/pdb5jo0/pdb
• 分子名称: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, [(2R)-2-{2-[hydroxy(methyl)amino]-2-oxoethyl}-5-(3-methylphenyl)pentyl]phosphonic acid, MANGANESE (II) ION, ... (7 entities in total)
• 機能のキーワード: enzyme-inhibitor complex, mep pathway, isoprenoid biosynthesis, oxidoreductase
• 由来する生物種: Plasmodium falciparum 3D7
• 細胞内の位置: Plastid, apicoplast : Q8IKG4
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98049.53

構造登録者

Sooriyaarachchi, S.,Bergfors, T.,Jones, T.A.,Mowbray, S.L. (登録日: 2016-05-01, 公開日: 2016-08-24, 最終更新日: 2024-01-10)

• 主引用文献: Sooriyaarachchi, S.,Chofor, R.,Risseeuw, M.D.,Bergfors, T.,Pouyez, J.,Dowd, C.S.,Maes, L.,Wouters, J.,Jones, T.A.,Van Calenbergh, S.,Mowbray, S.L.; Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with beta-Arylpropyl Analogues of Fosmidomycin.; Chemmedchem, 11:2024-2036, 2016; PubMed: 27487410; DOI: 10.1002/cmdc.201600249

実験手法

X-RAY DIFFRACTION (1.8 Å)