5JLJ

Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1

Summary for 5JLJ

Entry DOI	10.2210/pdb5jlj/pdb
Descriptor	GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (9 entities in total)
Functional Keywords	heat repeat, exportin-1, nuclear transport, transport receptor-inhibitor complex, protein transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	162225.08
Authors	Fung, H.Y.,Chook, Y.M. (deposition date: 2016-04-27, release date: 2016-06-29, Last modification date: 2023-09-27)
Primary citation	Hing, Z.A.,Fung, H.Y.,Ranganathan, P.,Mitchell, S.,El-Gamal, D.,Woyach, J.A.,Williams, K.,Goettl, V.M.,Smith, J.,Yu, X.,Meng, X.,Sun, Q.,Cagatay, T.,Lehman, A.M.,Lucas, D.M.,Baloglu, E.,Shacham, S.,Kauffman, M.G.,Byrd, J.C.,Chook, Y.M.,Garzon, R.,Lapalombella, R. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia, 30:2364-2372, 2016 Cited by PubMed: 27323910 DOI: 10.1038/leu.2016.136 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation