5JHU

Potent, Reversible MetAP2 Inhibitors via FBDD

Summary for 5JHU

Entry DOI	10.2210/pdb5jhu/pdb
Descriptor	Methionine aminopeptidase 2, MANGANESE (II) ION, GLYCEROL, ... (6 entities in total)
Functional Keywords	hydrolase, peptidase, metal ion binding, proteolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P50579
Total number of polymer chains	1
Total formula weight	41989.45
Authors	Dougan, D.R. (deposition date: 2016-04-21, release date: 2016-05-25, Last modification date: 2017-11-22)
Primary citation	Cheruvallath, Z.,Tang, M.,McBride, C.,Komandla, M.,Miura, J.,Ton-Nu, T.,Erikson, P.,Feng, J.,Farrell, P.,Lawson, J.D.,Vanderpool, D.,Wu, Y.,Dougan, D.R.,Plonowski, A.,Holub, C.,Larson, C. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design-Part 1. Bioorg.Med.Chem.Lett., 26:2774-2778, 2016 Cited by PubMed: 27155900 DOI: 10.1016/j.bmcl.2016.04.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation