5JGD
Crystal structure of human TAK1/TAB1 fusion protein in complex with ligand 12
Summary for 5JGD
| Entry DOI | 10.2210/pdb5jgd/pdb |
| Related | 5JGA 5JGB |
| Descriptor | TAK1 kinase - TAB1 chimera fusion protein, N-(2-isopropoxy-3-(4-methylpiperazine-1-carbonyl)phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide (3 entities in total) |
| Functional Keywords | transferase-transferase inhibitor complex, tak1-tab1 kinase, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 1 |
| Total formula weight | 35986.48 |
| Authors | Irie, M.,Nakamura, M.,Fukami, T.A.,Matsuura, T.,Morishima, K. (deposition date: 2016-04-20, release date: 2016-07-27, Last modification date: 2023-11-08) |
| Primary citation | Muraoka, T.,Ide, M.,Morikami, K.,Irie, M.,Nakamura, M.,Miura, T.,Kamikawa, T.,Nishihara, M.,Kashiwagi, H. Discovery of a potent and highly selective transforming growth factor beta receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD) Bioorg.Med.Chem., 24:4206-4217, 2016 Cited by PubMed: 27448772DOI: 10.1016/j.bmc.2016.07.006 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.101 Å) |
Structure validation
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