5JEB

Crystal structure of EGFR tyrosine kinase domain with novel inhibitor of active state of HER2

Summary for 5JEB

Entry DOI	10.2210/pdb5jeb/pdb
Descriptor	Epidermal growth factor receptor, SULFATE ION, 3-(furan-2-yl)-N-[5-(furan-2-yl)-2-methoxyphenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine (3 entities in total)
Functional Keywords	inhibitor, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	39122.07
Authors	Park, J.H.,Lemmon, M.A. (deposition date: 2016-04-18, release date: 2016-09-07, Last modification date: 2023-09-27)
Primary citation	Novotny, C.J.,Pollari, S.,Park, J.H.,Lemmon, M.A.,Shen, W.,Shokat, K.M. Overcoming resistance to HER2 inhibitors through state-specific kinase binding. Nat.Chem.Biol., 12:923-930, 2016 Cited by PubMed: 27595329 DOI: 10.1038/nchembio.2171 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.298 Å)

Structure validation