5JD7

PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with PET-cGMP

Summary for 5JD7

• Entry DOI: 10.2210/pdb5jd7/pdb
• Descriptor: cGMP-dependent protein kinase 1, 3-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one (3 entities in total)
• Functional Keywords: binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, analogs
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : Q13976
• Total number of polymer chains: 1
• Total formula weight: 15432.06

Authors

Campbell, J.C.,Sankaran, B.,Kim, C.W. (deposition date: 2016-04-15, release date: 2017-08-09, Last modification date: 2023-09-27)

• Primary citation: Campbell, J.C.,Henning, P.,Franz, E.,Sankaran, B.,Herberg, F.W.,Kim, C.; Structural Basis of Analog Specificity in PKG I and II.; ACS Chem. Biol., 12:2388-2398, 2017; PubMed: 28793191; DOI: 10.1021/acschembio.7b00369

Experimental method

X-RAY DIFFRACTION (1.749 Å)