5JA0

Crystal structure of human FPPS with allosterically bound FPP

Summary for 5JA0

Entry DOI	10.2210/pdb5ja0/pdb
Descriptor	Farnesyl pyrophosphate synthase, PHOSPHATE ION, FARNESYL DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: P14324
Total number of polymer chains	1
Total formula weight	43622.28
Authors	Park, J.,Zielinski, M.,Tsantrizos, Y.S.,Berghuis, A.M. (deposition date: 2016-04-11, release date: 2017-01-25, Last modification date: 2023-09-27)
Primary citation	Park, J.,Zielinski, M.,Magder, A.,Tsantrizos, Y.S.,Berghuis, A.M. Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product. Nat Commun, 8:14132-14132, 2017 Cited by PubMed: 28098152 DOI: 10.1038/ncomms14132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation