5J94

Human cathepsin K mutant C25S in complex with the allosteric effector NSC13345

Replaces:  4LEG

Summary for 5J94

• Entry DOI: 10.2210/pdb5j94/pdb
• Descriptor: Cathepsin K, 2-{[(carbamoylsulfanyl)acetyl]amino}benzoic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: cysteine proteases, allosteric regulation, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Lysosome: P43235
• Total number of polymer chains: 1
• Total formula weight: 24889.87

Authors

Novinec, M.,Korenc, M.,Lenarcic, B.,Baici, A. (deposition date: 2016-04-08, release date: 2016-04-20, Last modification date: 2024-01-10)

• Primary citation: Novinec, M.,Korenc, M.,Caflisch, A.,Ranganathan, R.,Lenarcic, B.,Baici, A.; A novel allosteric mechanism in the cysteine peptidase cathepsin K discovered by computational methods.; Nat Commun, 5:3287-, 2014; PubMed: 24518821; DOI: 10.1038/ncomms4287

Experimental method

X-RAY DIFFRACTION (2.22002456664 Å)