5J89

Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor

Summary for 5J89

• Entry DOI: 10.2210/pdb5j89/pdb
• Descriptor: Programmed cell death 1 ligand 1, N-{2-[({2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: pd-l1, programmed cell death 1 ligand 1, cell cycle, immune system
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Cell membrane ; Single-pass type I membrane protein . Isoform 2: Endomembrane system ; Single-pass type I membrane protein : Q9NZQ7
• Total number of polymer chains: 4
• Total formula weight: 67838.12

Authors

Zak, K.M.,Grudnik, P.,Guzik, K.,Zieba, B.J.,Musielak, B.,Doemling, P.,Dubin, G.,Holak, T.A. (deposition date: 2016-04-07, release date: 2016-04-27, Last modification date: 2024-01-10)

• Primary citation: Zak, K.M.,Grudnik, P.,Guzik, K.,Zieba, B.J.,Musielak, B.,Domling, A.,Dubin, G.,Holak, T.A.; Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).; Oncotarget, 7:30323-30335, 2016; PubMed: 27083005; DOI: 10.18632/oncotarget.8730

Experimental method

X-RAY DIFFRACTION (2.2 Å)