5J5Y

Translation initiation factor 4E in complex with m2(7,2'O)GppCCl2ppG mRNA 5' cap analog

Summary for 5J5Y

Entry DOI	10.2210/pdb5j5y/pdb
Descriptor	Eukaryotic translation initiation factor 4E, 2-amino-9-{5-O-[(R)-{[(S)-{dichloro[(R)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]-2-O-methyl-beta-D-ribofuranosyl}-7-methyl-9H-purin-7-ium-6-olate, GLYCEROL, ... (4 entities in total)
Functional Keywords	protein-ligand complex, translation initiation factor, eif4e, m2(7, 2'o)gppccl2ppg, dichloromethylenebisphosphonate, mrna 5' cap analog, translation
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	90068.81
Authors	Warminski, M.,Nowak, E.,Rydzik, A.M.,Kowalska, J.,Jemielity, J.,Nowotny, M. (deposition date: 2016-04-04, release date: 2017-05-10, Last modification date: 2024-01-10)
Primary citation	Rydzik, A.M.,Warminski, M.,Sikorski, P.J.,Baranowski, M.R.,Walczak, S.,Kowalska, J.,Zuberek, J.,Lukaszewicz, M.,Nowak, E.,W Claridge, T.D.,Darzynkiewicz, E.,Nowotny, M.,Jemielity, J. mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Res., 45:8661-8675, 2017 Cited by PubMed: 28666355 DOI: 10.1093/nar/gkx569 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation