5J40

The X-ray structure of JCV Helicase

Summary for 5J40

Entry DOI	10.2210/pdb5j40/pdb
Related	5J47 5J4V 5J4Y
Descriptor	Large T antigen, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
Functional Keywords	helicase, hexamer, zn, atp, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	JC polyomavirus (JCPyV)
Cellular location	Host nucleus : P03072
Total number of polymer chains	1
Total formula weight	42745.69
Authors	Ter Haar, E. (deposition date: 2016-03-31, release date: 2016-07-20, Last modification date: 2024-03-06)
Primary citation	Bonafoux, D.,Nanthakumar, S.,Bandarage, U.K.,Memmott, C.,Lowe, D.,Aronov, A.M.,Bhisetti, G.R.,Bonanno, K.C.,Coll, J.,Leeman, J.,Lepre, C.A.,Lu, F.,Perola, E.,Rijnbrand, R.,Taylor, W.P.,Wilson, D.,Zhou, Y.,Zwahlen, J.,Ter Haar, E. Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors. J.Med.Chem., 59:7138-7151, 2016 Cited by PubMed: 27385654 DOI: 10.1021/acs.jmedchem.6b00486 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.17 Å)

Structure validation