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5J3Z

Crystal structure of m2hTDP2-CAT in complex with a small molecule inhibitor

Summary for 5J3Z
Entry DOI10.2210/pdb5j3z/pdb
DescriptorTyrosyl-DNA phosphodiesterase 2, 2,4-dioxo-10-[3-(1H-tetrazol-5-yl)phenyl]-2,3,4,10-tetrahydropyrimido[4,5-b]quinoline-8-carbonitrile, MAGNESIUM ION, ... (7 entities in total)
Functional Keywordstyrosyl dna phosphodiesterase 2 catalytic domain, hydrolase
Biological sourceMus musculus (House Mouse)
Cellular locationNucleus : Q9JJX7
Total number of polymer chains2
Total formula weight60019.27
Authors
Hornyak, P.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W. (deposition date: 2016-03-31, release date: 2016-05-04, Last modification date: 2024-01-10)
Primary citationHornyak, P.,Askwith, T.,Walker, S.,Komulainen, E.,Paradowski, M.,Pennicott, L.E.,Bartlett, E.J.,Brissett, N.C.,Raoof, A.,Watson, M.,Jordan, A.M.,Ogilvie, D.J.,Ward, S.E.,Atack, J.R.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473:1869-1879, 2016
Cited by
PubMed: 27099339
DOI: 10.1042/BCJ20160180
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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