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5J3P

Crystal structure of the catalytic domain of human tyrosyl DNA phosphodiesterase 2

Summary for 5J3P
Entry DOI10.2210/pdb5j3p/pdb
DescriptorTyrosyl-DNA phosphodiesterase 2, MAGNESIUM ION, GLYCEROL, ... (4 entities in total)
Functional Keywordstyrosyl, dna phosphodiesterase 2, catalytic domain, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: O95551
Total number of polymer chains2
Total formula weight57789.33
Authors
Hornyak, P.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W. (deposition date: 2016-03-31, release date: 2016-05-04, Last modification date: 2024-01-10)
Primary citationHornyak, P.,Askwith, T.,Walker, S.,Komulainen, E.,Paradowski, M.,Pennicott, L.E.,Bartlett, E.J.,Brissett, N.C.,Raoof, A.,Watson, M.,Jordan, A.M.,Ogilvie, D.J.,Ward, S.E.,Atack, J.R.,Pearl, L.H.,Caldecott, K.W.,Oliver, A.W.
Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
Biochem.J., 473:1869-1879, 2016
Cited by
PubMed: 27099339
DOI: 10.1042/BCJ20160180
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

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