5IZF
Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1408
Summary for 5IZF
Entry DOI | 10.2210/pdb5izf/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, 6J9-ZEU-DAR-ACA-DAR-NH2, SULFATE ION, ... (4 entities in total) |
Functional Keywords | protein kinase, inhibitor, bisubstrate, oligoarginine, pka, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform 2: Cell projection, cilium, flagellum: P17612 |
Total number of polymer chains | 2 |
Total formula weight | 41991.82 |
Authors | Pflug, A.,Enkvist, E.,Uri, A.,Engh, R.A. (deposition date: 2016-03-25, release date: 2016-07-20, Last modification date: 2024-01-10) |
Primary citation | Ivan, T.,Enkvist, E.,Viira, B.,Manoharan, G.B.,Raidaru, G.,Pflug, A.,Alam, K.A.,Zaccolo, M.,Engh, R.A.,Uri, A. Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions. Bioconjug.Chem., 27:1900-1910, 2016 Cited by PubMed: 27389935DOI: 10.1021/acs.bioconjchem.6b00293 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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