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5IZF

Complex of PKA with the bisubstrate protein kinase inhibitor ARC-1408

Summary for 5IZF
Entry DOI10.2210/pdb5izf/pdb
DescriptorcAMP-dependent protein kinase catalytic subunit alpha, 6J9-ZEU-DAR-ACA-DAR-NH2, SULFATE ION, ... (4 entities in total)
Functional Keywordsprotein kinase, inhibitor, bisubstrate, oligoarginine, pka, transferase
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm. Isoform 2: Cell projection, cilium, flagellum: P17612
Total number of polymer chains2
Total formula weight41991.82
Authors
Pflug, A.,Enkvist, E.,Uri, A.,Engh, R.A. (deposition date: 2016-03-25, release date: 2016-07-20, Last modification date: 2024-01-10)
Primary citationIvan, T.,Enkvist, E.,Viira, B.,Manoharan, G.B.,Raidaru, G.,Pflug, A.,Alam, K.A.,Zaccolo, M.,Engh, R.A.,Uri, A.
Bifunctional Ligands for Inhibition of Tight-Binding Protein-Protein Interactions.
Bioconjug.Chem., 27:1900-1910, 2016
Cited by
PubMed: 27389935
DOI: 10.1021/acs.bioconjchem.6b00293
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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