5IWL

CD47-diabody complex

Summary for 5IWL

• Entry DOI: 10.2210/pdb5iwl/pdb
• Descriptor: 5F9 diabody, Leukocyte surface antigen CD47, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: receptor, diabody, complex, cell adhesion
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 78365.33

Authors

Di, W.,Jude, K.M.,Garcia, K.C. (deposition date: 2016-03-22, release date: 2016-06-29, Last modification date: 2020-07-29)

• Primary citation: Weiskopf, K.,Jahchan, N.S.,Schnorr, P.J.,Cristea, S.,Ring, A.M.,Maute, R.L.,Volkmer, A.K.,Volkmer, J.P.,Liu, J.,Lim, J.S.,Yang, D.,Seitz, G.,Nguyen, T.,Wu, D.,Jude, K.,Guerston, H.,Barkal, A.,Trapani, F.,George, J.,Poirier, J.T.,Gardner, E.E.,Miles, L.A.,de Stanchina, E.,Lofgren, S.M.,Vogel, H.,Winslow, M.M.,Dive, C.,Thomas, R.K.,Rudin, C.M.,van de Rijn, M.,Majeti, R.,Garcia, K.C.,Weissman, I.L.,Sage, J.; CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer.; J.Clin.Invest., 126:2610-2620, 2016; PubMed: 27294525; DOI: 10.1172/JCI81603

Experimental method

X-RAY DIFFRACTION (2.8 Å)