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5IVE

Linked KDM5A Jmj Domain Bound to the Inhibitor N8 ( 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile)

Summary for 5IVE
Entry DOI10.2210/pdb5ive/pdb
Related5ISL 5IVB 5IVC 5IVF 5IVJ 5IVV 5IVY 5IW0 5IWF
DescriptorLysine-specific demethylase 5A, 5-methyl-7-oxo-6-(propan-2-yl)-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywordsdemethylase inhibition, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleolus : P29375
Total number of polymer chains1
Total formula weight38216.01
Authors
Horton, J.R.,Cheng, X. (deposition date: 2016-03-20, release date: 2016-07-27, Last modification date: 2023-09-27)
Primary citationHorton, J.R.,Liu, X.,Gale, M.,Wu, L.,Shanks, J.R.,Zhang, X.,Webber, P.J.,Bell, J.S.,Kales, S.C.,Mott, B.T.,Rai, G.,Jansen, D.J.,Henderson, M.J.,Urban, D.J.,Hall, M.D.,Simeonov, A.,Maloney, D.J.,Johns, M.A.,Fu, H.,Jadhav, A.,Vertino, P.M.,Yan, Q.,Cheng, X.
Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
Cell Chem Biol, 23:769-781, 2016
Cited by
PubMed: 27427228
DOI: 10.1016/j.chembiol.2016.06.006
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.783 Å)
Structure validation

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