5IQB
Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPNP, Magnesium, and Kanamycin A
Summary for 5IQB
Entry DOI | 10.2210/pdb5iqb/pdb |
Related | 5BYL 5IQA 5IQC 5IQD 5IQE 5IQF 5IQG 5IQH 5IQI |
Descriptor | Bifunctional AAC/APH, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, KANAMYCIN A, ... (6 entities in total) |
Functional Keywords | kinase, antibiotic, aminoglycoside, resistance, transferase |
Biological source | Staphylococcus aureus |
Cellular location | Cytoplasm: P0A0C1 |
Total number of polymer chains | 4 |
Total formula weight | 148109.23 |
Authors | Caldwell, S.J.,Berghuis, A.M. (deposition date: 2016-03-10, release date: 2016-05-25, Last modification date: 2023-09-27) |
Primary citation | Caldwell, S.J.,Huang, Y.,Berghuis, A.M. Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia. Structure, 24:935-945, 2016 Cited by PubMed: 27161980DOI: 10.1016/j.str.2016.04.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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