5IQ6

Crystal structure of Dengue virus serotype 3 RNA dependent RNA polymerase bound to HeE1-2Tyr, a new pyridobenzothizole inhibitor

Summary for 5IQ6

Entry DOI	10.2210/pdb5iq6/pdb
Descriptor	RNA dependent RNA polymerase, ZINC ION, N-[8-(cyclohexyloxy)-1-oxo-2-phenyl-1H-pyrido[2,1-b][1,3]benzothiazole-4-carbonyl]-L-tyrosine, ... (4 entities in total)
Functional Keywords	rna dependent rna polymerase, hydrolase
Biological source	Dengue virus 3
Cellular location	Virion membrane ; Multi-pass membrane protein : Q6DLV0
Total number of polymer chains	1
Total formula weight	73582.53
Authors	Tarantino, D.,Mastrangelo, E.,Milani, M. (deposition date: 2016-03-10, release date: 2016-10-05, Last modification date: 2016-10-12)
Primary citation	Tarantino, D.,Cannalire, R.,Mastrangelo, E.,Croci, R.,Querat, G.,Barreca, M.L.,Bolognesi, M.,Manfroni, G.,Cecchetti, V.,Milani, M. Targeting flavivirus RNA dependent RNA polymerase through a pyridobenzothiazole inhibitor. Antiviral Res., 134:226-235, 2016 Cited by PubMed: 27649989 DOI: 10.1016/j.antiviral.2016.09.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation