5IPD

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) nucleoside thiophosphoramidate covalent intermediate complex

Summary for 5IPD

• Entry DOI: 10.2210/pdb5ipd/pdb
• Related: 1KPA 3TW2 4EQE 4EQG 4EQH 5I2E 5I2F 5IPB 5IPC 5IPE
• Descriptor: Histidine triad nucleotide-binding protein 1, 5'-S-phosphono-5'-thioguanosine (3 entities in total)
• Functional Keywords: hint, histidine triad, hit, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P49773
• Total number of polymer chains: 2
• Total formula weight: 28571.66

Authors

Maize, K.M.,Finzel, B.C. (deposition date: 2016-03-09, release date: 2017-03-15, Last modification date: 2017-07-26)

• Primary citation: Shah, R.,Maize, K.M.,Zhou, X.,Finzel, B.C.,Wagner, C.R.; Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).; Biochemistry, 56:3559-3570, 2017; PubMed: 28691797; DOI: 10.1021/acs.biochem.7b00148

Experimental method

X-RAY DIFFRACTION (1.75 Å)