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5IKV

The Structure of Flufenamic Acid Bound to Human Cyclooxygenase-2

Summary for 5IKV
Entry DOI10.2210/pdb5ikv/pdb
Related5IKQ 5IKR 5IKT
DescriptorProstaglandin G/H synthase 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, ... (8 entities in total)
Functional Keywordscox flufenamic, oxidoreductase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight130722.49
Authors
Orlando, B.J.,Malkowski, M.G. (deposition date: 2016-03-03, release date: 2016-05-25, Last modification date: 2020-07-29)
Primary citationOrlando, B.J.,Malkowski, M.G.
Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone.
J.Biol.Chem., 291:15069-15081, 2016
Cited by
PubMed: 27226593
DOI: 10.1074/jbc.M116.725713
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.508 Å)
Structure validation

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