5IH5

Human Casein Kinase 1 isoform delta (kinase domain) in complex with Epiblastin A

Summary for 5IH5

• Entry DOI: 10.2210/pdb5ih5/pdb
• Descriptor: Casein kinase I isoform delta, ZINC ION, 6-(3-chlorophenyl)pteridine-2,4,7-triamine, ... (6 entities in total)
• Functional Keywords: kinase domain, stem cell reprogramming, kinase inhibitor complex, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P48730
• Total number of polymer chains: 1
• Total formula weight: 34901.86

Authors

Ursu, A.,Illich, D.J.,Takemoto, Y.,Porfetye, A.T.,Zhang, M.,Brockmeyer, A.,Janning, P.,Watanabe, N.,Osada, H.,Vetter, I.R.,Ziegler, S.,Schoeler, H.R.,Waldmann, H. (deposition date: 2016-02-29, release date: 2016-04-13, Last modification date: 2024-01-10)

• Primary citation: Ursu, A.,Illich, D.J.,Takemoto, Y.,Porfetye, A.T.,Zhang, M.,Brockmeyer, A.,Janning, P.,Watanabe, N.,Osada, H.,Vetter, I.R.,Ziegler, S.,Scholer, H.R.,Waldmann, H.; Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1.; Cell Chem Biol, 23:494-507, 2016; PubMed: 27049670; DOI: 10.1016/j.chembiol.2016.02.015

Experimental method

X-RAY DIFFRACTION (2.25 Å)