5IFW

Quantitative interaction mapping reveals an extended ubiquitin regulatory domain in ASPL that disrupts functional p97 hexamers and induces cell death

Summary for 5IFW

Entry DOI	10.2210/pdb5ifw/pdb
Descriptor	Tether containing UBX domain for GLUT4, Transitional endoplasmic reticulum ATPase, ADENOSINE-5'-DIPHOSPHATE, ... (4 entities in total)
Functional Keywords	aspl, p97, disassembly, hexamer, eubx, signaling protein
Biological source	Homo sapiens (Human) More
Cellular location	Endomembrane system ; Peripheral membrane protein : Q9BZE9 Cytoplasm, cytosol: P55072
Total number of polymer chains	2
Total formula weight	111660.54
Authors	Roske, Y.,Heinemann, U. (deposition date: 2016-02-26, release date: 2016-10-26, Last modification date: 2024-01-10)
Primary citation	Arumughan, A.,Roske, Y.,Barth, C.,Forero, L.L.,Bravo-Rodriguez, K.,Redel, A.,Kostova, S.,McShane, E.,Opitz, R.,Faelber, K.,Rau, K.,Mielke, T.,Daumke, O.,Selbach, M.,Sanchez-Garcia, E.,Rocks, O.,Panakova, D.,Heinemann, U.,Wanker, E.E. Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers. Nat Commun, 7:13047-13047, 2016 Cited by PubMed: 27762274 DOI: 10.1038/ncomms13047 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation