5IEI

X-ray crystallographic structure of a high affinity IGF2 antagonist (Domain11 AB5 RHH) based on human IGF2R domain 11

Summary for 5IEI

Entry DOI	10.2210/pdb5iei/pdb
Related	1GP0 2L29 2L2A 2M68 2M6T
Descriptor	Cation-independent mannose-6-phosphate receptor, GLYCEROL, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	igf2, igf2r, domain 11, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15963.11
Authors	Nicholls, R.D.,Williams, C.,Strickland, M.,Frago, S.,Hassan, A.B.,Crump, M.P. (deposition date: 2016-02-25, release date: 2016-05-18, Last modification date: 2024-01-10)
Primary citation	Frago, S.,Nicholls, R.D.,Strickland, M.,Hughes, J.,Williams, C.,Garner, L.,Surakhy, M.,Maclean, R.,Rezgui, D.,Prince, S.N.,Zaccheo, O.J.,Ebner, D.,Sanegre, S.,Yu, S.,Buffa, F.M.,Crump, M.P.,Hassan, A.B. Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist. Proc.Natl.Acad.Sci.USA, 113:E2766-E2775, 2016 Cited by PubMed: 27140600 DOI: 10.1073/pnas.1513023113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation