5IBK
Skp1-F-box in complex with a ubiquitin variant
Summary for 5IBK
Entry DOI | 10.2210/pdb5ibk/pdb |
Descriptor | S-phase kinase-associated protein 1,S-phase kinase-associated protein 1, F-box/WD repeat-containing protein 7, Polyubiquitin-B, ... (4 entities in total) |
Functional Keywords | phage display, scf inhibitors, fbxw7, fbxw11, ?-trcp, ubiquitin, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 66612.28 |
Authors | Orlicky, S.,Sicheri, F. (deposition date: 2016-02-22, release date: 2016-03-30, Last modification date: 2023-09-27) |
Primary citation | Gorelik, M.,Orlicky, S.,Sartori, M.A.,Tang, X.,Marcon, E.,Kurinov, I.,Greenblatt, J.F.,Tyers, M.,Moffat, J.,Sicheri, F.,Sidhu, S.S. Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc.Natl.Acad.Sci.USA, 113:3527-3532, 2016 Cited by PubMed: 26976582DOI: 10.1073/pnas.1519389113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.503 Å) |
Structure validation
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