5IAW

Novel natural FXR modulator with a unique binding mode

Summary for 5IAW

• Entry DOI: 10.2210/pdb5iaw/pdb
• Descriptor: Bile acid receptor, Peptide from Nuclear receptor coactivator 2, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate, ... (4 entities in total)
• Functional Keywords: nuclear protein receptor, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1
• Total number of polymer chains: 4
• Total formula weight: 56611.34

Authors

Lu, Y.,Li, Y. (deposition date: 2016-02-22, release date: 2017-03-08, Last modification date: 2024-03-20)

• Primary citation: Zheng, W.,Lu, Y.,Lin, S.,Wang, R.,Qiu, L.,Zhu, Y.,Yao, B.,Guo, F.,Jin, S.,Jin, L.,Li, Y.; A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly; Chembiochem, 18:721-725, 2017; PubMed: 28186695; DOI: 10.1002/cbic.201700059

Experimental method

X-RAY DIFFRACTION (2.58 Å)