5I9Z

Crystal Structure of Ephrin A2 (EphA2) Receptor Protein Kinase with danusertib (PHA739358)

Summary for 5I9Z

Entry DOI	10.2210/pdb5i9z/pdb
Descriptor	Ephrin type-A receptor 2, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transferase, tyrosine-protein kinase, receptor, atp-binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	34999.46
Authors	Kudlinzki, D.,Linhard, V.L.,Gande, S.L.,Sreeramulu, S.,Saxena, K.,Heinzlmeir, S.,Medard, G.,Kuester, B.,Schwalbe, H. (deposition date: 2016-02-21, release date: 2016-11-09, Last modification date: 2024-01-10)
Primary citation	Heinzlmeir, S.,Kudlinzki, D.,Sreeramulu, S.,Klaeger, S.,Gande, S.L.,Linhard, V.,Wilhelm, M.,Qiao, H.,Helm, D.,Ruprecht, B.,Saxena, K.,Medard, G.,Schwalbe, H.,Kuster, B. Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem. Biol., 11:3400-3411, 2016 Cited by PubMed: 27768280 DOI: 10.1021/acschembio.6b00709 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.698 Å)

Structure validation