5I80

BRD4 in complex with Cpd2 (N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide)

Summary for 5I80

• Entry DOI: 10.2210/pdb5i80/pdb
• Related: 5I7X
• Descriptor: Bromodomain-containing protein 4, N,N-dimethyl-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: brd4, bromodomain, epigenetics, structure-based drug design, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: O60885
• Total number of polymer chains: 1
• Total formula weight: 15437.78

Authors

Murray, J.M. (deposition date: 2016-02-18, release date: 2016-10-12, Last modification date: 2024-03-06)

• Primary citation: Crawford, T.D.,Tsui, V.,Flynn, E.M.,Wang, S.,Taylor, A.M.,Cote, A.,Audia, J.E.,Beresini, M.H.,Burdick, D.J.,Cummings, R.,Dakin, L.A.,Duplessis, M.,Good, A.C.,Hewitt, M.C.,Huang, H.R.,Jayaram, H.,Kiefer, J.R.,Jiang, Y.,Murray, J.,Nasveschuk, C.G.,Pardo, E.,Poy, F.,Romero, F.A.,Tang, Y.,Wang, J.,Xu, Z.,Zawadzke, L.E.,Zhu, X.,Albrecht, B.K.,Magnuson, S.R.,Bellon, S.,Cochran, A.G.; Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.; J.Med.Chem., 59:5391-5402, 2016; PubMed: 27219867; DOI: 10.1021/acs.jmedchem.6b00264

Experimental method

X-RAY DIFFRACTION (1.4501 Å)