5I76

Crystal structure of FM318, a recombinant Fab adopted from cetuximab

Summary for 5I76

• Entry DOI: 10.2210/pdb5i76/pdb
• Descriptor: FM318_light_chain, FM318_heavy_cahin (3 entities in total)
• Functional Keywords: antibody fragment, recombinant fab, cetuximab, egfr, immune system
• Biological source: Homo sapiens/Mus musculus xenograft; More
• Total number of polymer chains: 4
• Total formula weight: 95185.76

Authors

Sim, D.W.,Kim, J.H.,Seok, S.H.,Seo, M.D.,Kim, Y.P.,Won, H.S. (deposition date: 2016-02-16, release date: 2016-12-07, Last modification date: 2023-11-08)

• Primary citation: Kim, J.H.,Sim, D.W.,Park, D.,Jung, T.G.,Lee, S.,Oh, T.,Ha, J.R.,Seok, S.H.,Seo, M.D.,Kang, H.C.,Kim, Y.P.,Won, H.S.; Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor.; Appl.Microbiol.Biotechnol., 100:10521-10529, 2016; PubMed: 27470143; DOI: 10.1007/s00253-016-7717-z

Experimental method

X-RAY DIFFRACTION (1.922 Å)