5I2N

Structure of the human GluN1/GluN2A LBD in complex with N-ethyl-7-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 29)

Summary for 5I2N

• Entry DOI: 10.2210/pdb5i2n/pdb
• Related: 5I2J 5I2K
• Descriptor: Glutamate receptor ionotropic, NMDA 2A, Glutamate receptor ionotropic, NMDA 1, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: nmda, receptor, glutamate, channel, transport protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: Q12879 Q05586
• Total number of polymer chains: 2
• Total formula weight: 66206.48

Authors

Wallweber, H.J.A.,Lupardus, P.J. (deposition date: 2016-02-09, release date: 2016-03-16, Last modification date: 2023-09-27)

• Primary citation: Volgraf, M.,Sellers, B.D.,Jiang, Y.,Wu, G.,Ly, C.Q.,Villemure, E.,Pastor, R.M.,Yuen, P.W.,Lu, A.,Luo, X.,Liu, M.,Zhang, S.,Sun, L.,Fu, Y.,Lupardus, P.J.,Wallweber, H.J.,Liederer, B.M.,Deshmukh, G.,Plise, E.,Tay, S.,Reynen, P.,Herrington, J.,Gustafson, A.,Liu, Y.,Dirksen, A.,Dietz, M.G.,Liu, Y.,Wang, T.M.,Hanson, J.E.,Hackos, D.,Scearce-Levie, K.,Schwarz, J.B.; Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.; J.Med.Chem., 59:2760-2779, 2016; PubMed: 26919761; DOI: 10.1021/acs.jmedchem.5b02010

Experimental method

X-RAY DIFFRACTION (2.12 Å)