5HYR

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-SP2 and Estradiol

Summary for 5HYR

Entry DOI	10.2210/pdb5hyr/pdb
Related	5DX3 5DXB 5DXE 5DXG
Descriptor	Estrogen receptor, Stapled Peptide SRC2-SP2, ESTRADIOL, ... (5 entities in total)
Functional Keywords	breast cancer, estrogen receptor, synthetic peptide, stapled peptide, endocrine, hormone, gene regulation
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
Total number of polymer chains	4
Total formula weight	62073.18
Authors	Fanning, S.W.,Speltz, T.E.,Mayne, C.G.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. (deposition date: 2016-02-01, release date: 2016-05-25, Last modification date: 2023-11-15)
Primary citation	Speltz, T.E.,Fanning, S.W.,Mayne, C.G.,Fowler, C.,Tajkhorshid, E.,Greene, G.L.,Moore, T.W. Stapled Peptides with gamma-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew.Chem.Int.Ed.Engl., 55:4252-4255, 2016 Cited by PubMed: 26928945 DOI: 10.1002/anie.201510557 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.271 Å)

Structure validation